SHORT TEXT INFERENCE USING ENHANCED STRING SEMANTICS

The cryptography is created by obtaining AN in-depth neural network, that is trained on texts symbolized by word-count vectors (bag-of word representation). unfortunately, the conclusion result's texts for instance searches, tweets, or news titles, such representations inadequate to capture the linguistics. bunch short texts (for example news titles) by their which means could be a difficult task. The linguistics hashing approach encodes usually| this can be often  within the text within the compact code. Thus, to tell if 2 texts have similar meanings, we tend to merely check whether or not they have similar codes. To cluster short texts by their meanings, we tend to advise to incorporate a lot of linguistics signals to short texts. significantly, for each term inside the short text, we've got its ideas and co-occurring terms inside the probabilistic understanding base to boost fast text. additionally, we tend to introduce a simplified deep learning network comprised of the 3-layer stacked auto-encoders for linguistics hashing. Comprehensive experiments show, with elevated linguistics signals, our simplified deep learning model has the capability to capture the linguistics of short texts, which will facilitate various applications as well as short text retrieval, classification, and general purpose text process

QUALITATIVE ANALYSIS AND ANTHELMINTIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF TABERNAEMONTANA DIVARICATA

Tabernaemontana divaricata is a common shrub found in the tropical regions and is often used for medicinal purposes, particularly the flowers of the plant. The present study is conducted to compare and identify the phytochemical constituents by Thin Layer Chromatography (TLC) and Qualitative Phytochemical analysis and to determine the anthelmentic activity of fresh and dried flower extract of Tabernaemontana divaricata. The extract is obtained using two different methods like cold maceration and hot solvent extraction by using soxhlet apparatus, first with petroleum ether followed by hydroalcohol as solvents. The preliminary phytochemical analysis of the extract indicated the presence of Alkaloids, Flavanoids, Steroids, Proteins, Carbohydrates and Tannins. The Rf value of TLC is calculated and compared with standard values and analysis proved the presence of the phytochemical constituents. The anthelmentic activity studies are performed using Indian earth worms. For this, the concentrated extract is diluted to various concentrations, and the effect of each solution is studied by measuring the time taken for paralysis and death of the earth worms. It is found to show significant anthelmentic activity at various concentrations compared with that of the standard drug Metronidazole

A Location Based Value Prediction for Quality of Web Service

The number of web services with functionality increases, the service users usually depends on web recommendation systems. Now a days the service users pay more importance on non functional properties which are also known as Quality of Service (QoS) while finding and selecting appropriate web services. Collaborative filtering approach predicts the QoS values of the web services effectively. Existing recommendation systems rarely consider the personalized influence of the users and services in determining the similarity between users and services. The proposed system is a ranking oriented hybrid approach which integrates user-based and item-based QoS predictions. Many of the non-functional properties depends on the user and the service location. The system thus employs the location information of users and services in selecting similar neighbors for the target user and service and thereby making personalized service recommendation for service users

Study Design and Data Analysis of Artificial Pancreas Device Systems with Closed-Loop Glucose-Sensing Insulin Delivery

Objective: The objective of this article is to provide a high-profile review and discussion on the study design and statistical analysis of pivotal clinical trials conducted to demonstrate the safety and effectiveness of closed-loop investigational artificial pancreas device systems (APDSs) in premarket approval applications. Methods: The United States Food and Drug Administration (FDA) guidance on the content of investigational device exemption and premarket approval applications for APDSs is reviewed with special emphasis on study design and statistical analysis of the pivotal clinical trials. The two pivotal studies for the MiniMed 670G hybrid closed-loop system by Medtronic in their premarket approval application are summarized and discussed. Results: The United States FDA established detailed recommendations on the study design and statistical analysis of pivotal clinical trials for the industry that seek market investigational APDSs and for FDA scientific reviewers that regulate the device applications. The recommendations cover specifics regarding patient population, clinical endpoints, and strategies for data analysis. However, the two pivotal studies that demonstrated the effectiveness of the FDA-approved MiniMed 670G hybrid closed-loop system were not typical randomized controlled trials as per FDA recommendations. Conclusion: The development and regulation of investigational APDSs require careful and sophisticated clinical study designs and data analysis in premarket approval applications. The regulatory evaluation process of the APDSs is rather complicated since the devices consist of multiple components that collaboratively function to mimic human pancreases

ISOLATION AND EVALUATION OF SEED COAT CONSTITUENTS OF MORINGA OLEIFERA

Traditionally, Moringa oleifera seed powder has been used as eco-friendly clarifying agent for drinking water. Natural polysaccharides are widely used as excipients in pharmaceutical industry. In the present In vitro study, starch and protein-mucilage fractions were isolated from the seed coats of Moringa oleifera. The isolated fractions were evaluated as binder and disintegrant in the preparation of paracetamol tablets. The prepared tablets were assessed for comparative In vitro quality control parameters such as weight variation, hardness, friability and disintegration time. The parameters were compared with paracetamol tablets prepared using potato starch as binder and disintegrant. Significant variation was observed in hardness, friability, and disintegration time among three formulations. Paracetamol tablets with protein-mucilage fraction were found to be relatively harder, less friable, and taking more time to disintegrate than the tablets made with potato starch. The tablets with isolated starch fraction were found to be almost similar to tablets prepared with potato starch with respect to hardness, friability and disintegration time. The isolated starch fraction and protein-mucilage fractions exhibited good binding and disintegrating properties and were natural in origin, nontoxic, biodegradable and bio compatible. Hence, they could be employed as binding and disintegrating agents in the formulation of paracetamol immediate release dosage forms. Since the protein fraction showed relatively higher values of hardness and disintegration time with less friability and could be explored for designing sustained release paracetamol tablets. Key words: Moringa seeds, starch fraction, protein-mucilage fraction, Paracetamol tablets, binder and disintegrant Â

Synthesis of a New Class of Pyrazolyl-1,2,4-triazole Amine Derivatives

The olefin moiety presents in styrylsulfonylmethyl-1,2,4-triazolylamine (1) was exploited to build up five-member heterocycle-pyrazoles. The series of novel pyrazolyl-1,2,4-triazole amine derivatives (2-3) have been synthesized. All the entitles compounds were characterized by 1H and 13C NMR spectra. © 2022 Author(s).The authors G. Sravya and N. Bakkthavatchala Reddy are thankful to Ural Federal University, Yekaterinburg, Russia for financial assistance and thankful to Prof. V. Padmavathi for providing necessary lab facility to carry out this research work

Synthesis and Spectral Characterization of 1,2,4-triazole derivatives

The olefin moiety presents in styrylsulfonylmethyl-1,2,4-triazolylamine (1) was exploited to build up five-member heterocycle-pyrazoles. The series of novel pyrazolyl-1,2,4-triazole amine derivatives (2-3) have been synthesized. All the entitles compounds were characterized by 1H and 13C NMR spectra. © 2022 Author(s).The authors G. Sravya and N. Bakkthavatchala Reddy are thankful to Ural Federal University, Yekaterinburg, Russia for financial assistance and thankful to Prof. A. Padmaja for providing necessary lab facility to carry out this research work

Azolyl Pyrimidines-synthesis and Antimicrobial Activity

Amide unit is a privileged structural motif and is a constituent of proteins, natural products and pharmaceuticals. Amongst different heterocyclic scaffolds, azoles and pyrimidines are the prominent entities in pharmaceutical arena. The biopotency of these heterocycles have triggered to synthesize a variety of heteroaromatics - azoles linked with pyridines by amino acetamide group. The target molecules-azolylaminoacetamidopyrimidines were prepared by the reaction of methyl azolylglycinate with pyrimidinyl-2-amine in the presence of DMAP and triethylamine in dichloromethane under ultrasonication. The lead molecules were evaluated for antimicrobial activity. Nitro substituted 2-((4-(4-chlorofuran-2-yl)thiazole-2-yl)amino)-N-(4,6-diphenylpyrimidin-2-yl)acetamide (9c) displayed excellent antibacterial activity against B. subtilis greater than the standard drug Chloramphenicol. However, 9c and nitro substituted 2-((4-(4-chlorofuran-2-yl)-1H-imidazol-2-yl)amino)-N-(4,6-diphenylpyrimidin-2-yl)acetamide (10c) showed antifungal activity on A. niger greater than the standard drug Ketoconazole. © 2022 Author(s).The authors are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under major research project

Formulation and evaluation of oxymetazoline hydrochloride nasal gels

The main intend of the implement sniff out formulate and evaluate oxymetazoline nasal gels. To achieve more persistent blood levels with decrease dosage of medicine by extended drug evidence and by passing hepatic initially cross metabolism and body including inferable disgrace. Mod FTIR & DSC spectra there is not any discrepancein the seam clean medicine, polymers & lipids. The Carbopol consisting of reinforce precail eventual scintillating moreover transparent Poloxamer, Hydroxy Propyl Methyl cellulose gels crop up prospective lucent as a consequence frosted slimy. The pH value of all developed formulations of gels (ONGF1-ONGF8) was in the range of 6.2 to 6.9. Spreadability of gels was in the range 19.51 - 33.91 g.cm/sec, The Viscosity of various formulated gels was found in range of 8628 to 9622 centipoises. The percentage drug content of all prepared gel formulations were found to be in the range of 78.53 to 98.56 %. The gel strength of all prepared formulations of gels was found to be in the range of 69 to 96 %. In-vitro diffusion drug release of Oxymetazoline Hydrochloride of nasal gels ONGF1 shows the 95% drug release. The release order kinetics shows all the formulations ONGF1 to ONGF8 formulations were followed Korsemeyer-Peppas with correlation coefficient R2=0.8969 & 0.2692 respectively. ONGF1 formulation follows both Zero order and Korsmeyer-Peppas models, it indicates diffusion release mechanism followed by non-fickian transport. Keywords: Nasal, gels, Oxymetazoline, In vitro diffusion, Carbopol

Synthesis of a New Class of Pyrazolylsulfonyl Thiophene Carboxamides

A variety of pyrazolinylsulfonyl thiophenecarboxamides were prepared by using the olefin moiety present in styrylsulfonyl thiophenecarboxamides through 1,3-dipolar cycloaddition methodology. Oxidation of former compounds with chloranil in xylene gave pyrazolylsulfonyl thiophenecarboxamides. © 2019 Author(s)